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. 2016 Jan 11;48(3):1016–1028. doi: 10.3892/ijo.2016.3327

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Copyright: © Fang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Genistein modulates regulation of the cell cycle. (A) The cell cycle progression regulation by cyclin-CDKs. (B) CDK1 is hyperphosphorylated at Thr14 and Tyr15. The MS/MS spectrum of the phosphopeptide IGEGpTpYGVVYK is annotated (above) and the relative intensities of the TMT reporter ions show the changes of its phosphorylation (bottom). (C) Genistein-regulated phosphoproteins involved in DNA replication. (D) Genistein-induced changes of protein phosphorylation involved in DNA replication. (E) Genistein-regulated phosphoproteins involved in regulation of the cohesin complex. The legends are included in the inset. The expression level of the proteins in the figure remains unchanged or unquantifiable.