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. 2015 Dec 28;48(3):983–997. doi: 10.3892/ijo.2015.3313

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Copyright: © Katona et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The effect of ERK1/2 and PP2B inhibition on proliferation and migration of malignant cells. (A) Proliferation activity was assessed by [³H]-thymidine incorporation, applied on the second day of continuous PD098059 treatment. Data represent mean ± standard error of the average of three independent experiments. Asterisk indicates significant (^*P<0.05) increase in [³H]-thymidine incorporation as compared to the respective control. (B–D) Migration of different melanoma cell lines. Data represent mean ± standard error of the mean/average of 6 independent wells and presented in the average cell number of migrated cells. Representative data of 3 independent experiments. Asterisks indicate significant (^*P<0.05) decrease/increase in the number of migrated cells as compared to the respective control.