Table 2.
Comparison of perfusion parameters at baseline, 40 GYa CRTb and 66 Gy CRT stratified by response to CRT (n = 24).
Perfusion parameter | Responders (n = 12) |
Partial responders (n = 9) |
Static disease (n = 3) |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 40 Gy CRT | 66 Gy CRT | p-Value | Baseline | 40 Gy CRT | 66 Gy CRT | p-Value | Baseline | 40 Gy CRT | 66 Gy CRT | p-Value | |
BFc (ml/100 g/min) | 125.3 ± 25.7 | 122.7 ± 32.4 | 82.5 ± 36.3 | 0.002 | 86.7 ± 20.8 | 118.9 ± 39.1 | 85.4 ± 21.0 | 0.050 | 100.3 ± 56.5 | 92.1 ± 9.3 | 72.0 ± 28.5 | 0.264 |
BVd (ml/100 g) | 12.2 ± 3.5 | 13.8 ± 6.6 | 10.1 ± 5.9 | 0.005 | 8.4 ± 2.6 | 12.5 ± 7.0 | 7.5 ± 2.7 | 0.147 | 13.4 ± 6.7 | 7.7 ± 0.7 | 7.3 ± 3.1 | 0.097 |
MTTe (seconds) | 7.0 ± 1.2 | 7.1 ± 2.4 | 8.4 ± 2.2 | 0.024 | 7.1 ± 2.4 | 7.3 ± 2.2 | 6.2 ± 1.6 | 0.124 | 8.4 ± 1.5 | 5.7 ± 1.6 | 7.7 ± 0.9 | 0.178 |
PSf (ml/100 g/min) | 48.7 ± 10.6 | 48.7 ± 14.9 | 41.2 ± 23.6 | 0.233 | 58.4 ± 16.3 | 38.3 ± 20.2 | 36.7 ± 13.4 | 0.032 | 41.0 ± 28.6 | 54.7 ± 38.1 | 18.5 ± 8.3 | 0.097 |
Gray unit.
Chemo-radiotherapy.
Blood flow.
Blood volume.
Mean transit time.
Permeability Surface.