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Results of treatment with idursulfase in 17 MPS II patients. In the right upper corner of some figures the p-value is given. 1a shows the decrease of urinary glycosaminoglycans from baseline during ERT; 1b: individual ratio to normal of splenomegaly at baseline and at 2, 5–6 and 7–8 years of ERT are reported: after 5 years of treatment no patient has splenomegaly; and 1c: hepatomegaly decreased over time: only very mild hepatomegaly was found at 7–8 years of ERT.
