Fig. 3.

Histological, glycogen, and lipid analyses in the liver of 75–90 week-old wild type and AAV-LL mice. (A) H&E stained liver sections at original magnifications of × 200. Each plate represents an individual mouse. (B) Hepatic glycogen contents. (C) Hepatic triglyceride contents. (D) Oil red O staining at original magnifications of × 400 and quantification of oil red O staining. Each plate represents an individual mouse. (+/+), wild type mice (n = 8); AAV-LL (n = 6) are rAAV-GPE-treated G6pc^−/− mice expressing 0.5–1.3% of normal hepatic G6Pase-α activity. Data are presented as mean ± SEM. **P < 0.005.