Figure 2.

A proliferation assay was used to demonstrate functional blocking by FR104. This was compared to proliferation in the presence of cytotoxic T lymphocyte antigen 4 immunoglobulin (CTLA‐4 Ig) and cyclosporin A (CsA). The data are presented as the calculated percentage of inhibition relative to cultures with medium alone. (a) Inhibition of allogeneic responses of four major histocompatibility complex (MHC) class II mismatched peripheral blood mononuclear cells (PBMC) was calculated relative to medium alone for FR104, CTLA‐4 Ig and CsA (r1 a r2 = PBMC of rhesus monkey 1 responds to irradiated PBMC of rhesus monkey 2). (b) Inhibition of CII‐specific responses by FR104, CTLA‐4 Ig and CsA was calculated relative to medium alone for two animals that were immunized with collagen type II (CII) (rhesus 1, 2). Supporting information, Fig. S2 presents the data as stimulation indices.