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. 2015 Dec 16;183(3):405–418. doi: 10.1111/cei.12739

Figure 8.

Figure 8

Serum C‐reactive protein (CRP) and interleukin (IL)‐6 levels after treatment with placebo, FR104 and abatacept. The animals within each treatment group are colour‐coded. A colour represents the same animals for each graph within each treatment group (see also Fig. 6). (a–c) Longitudinal analysis of serum IL‐6 levels. Serum was collected 2×/week for each animal. (d–f) Longitudinal analysis of serum CRP levels. Serum was collected 2×/week for each animal. (g) The average serum IL‐6 level/day was calculated from the total production as determined by area under the curve analysis divided by the number of days the animals were in experiment. (h) The average serum CRP level/day was calculated from the total production as determined by area under the curve analysis divided by the number of days the animals were in experiment. Significance relative to placebo‐treated group was tested with the Mann–Whitney U‐test. *P < 0·05.