Table 1.
Demographic variables, clinical diagnosis and results from liver and renal function tests.
| Plausible diagnosis prior to liver biopsy | Age Mean ± SD |
Sex |
BMI Mean ± SD |
Bilirubina | ASTb | ALTc | ALPd | GGTe | Kreatininf | |
|---|---|---|---|---|---|---|---|---|---|---|
| Female No of subjects | Male No of subjects | |||||||||
| NAFLD | 49.5 ± 14.9 | 4 | 4 | 28.7 ± 3.4 | 10.1 ± 3.1 | 0.7 ± 0.2 | 1.4 ± 1.1 | 1.4 ± 0.8 | 1.4 ± 1.3 | 74.6 ± 17.3 |
| PSC | 42.0 ± 20.0 | 2 | 5 | 24.6 ± 3.2 | 10.4 ± 2.9 | 1.1 ± 0.6 | 2.1 ± 1.4 | 4.1 ± 3.0 | 8.6 ± 5.8 | 81.0 ± 16.0 |
| HCV | 49.0 ± 9.1 | 2 | 2 | 25.7 ± 1.1 | 10.8 ± 3.3 | 0.9 ± 0.3 | 1.1 ± 0.4 | 1.1 ± 0.3 | 2.7 ± 2.7 | 70.5 ± 8.7 |
| AIH | 47.0 ± 16.8 | 3 | 3 | 25.0 ± 4.2 | 21.0 ± 14.7 | 1.4 ± 0.8 | 2.5 ± 1.7 | 3.4 ± 2.7 | 5.0 ± 5.3 | 66 ± 10.1 |
| PBC | 48 | 1 | – | 24.2 | 8 | 0.8 | 0.9 | 1.4 | 1.3 | 76 |
| AAT-deficiency | 66 | 1 | – | 20.2 | 12 | 0.6 | 0.3 | 0.4 | 0.6 | 89 |
| DILI (thioguanine) | 48 | – | 1 | 28.4 | 15 | 0.5 | 0.6 | 0.8 | 0.4 | 82 |
| Unclear | 35 | – | 1 | 27.4 | 10 | 1.5 | 2.0 | 1.5 | 7.4 | 95 |
| 13 | 16 | |||||||||
NAFLD: non-alcoholic fatty liver disease; PSC: primary sclerosing cholangitis; HCV: hepatitis C virus; AIH: autoimmune hepatitis; PBC: primary biliary cholangitis; AAT-deficiency: α-1-anti-trypsine deficiency; DILI, drug-induced liver injury.
Reference value:
a
3–20 mol/L.
b
<0.76 kat/L (in men), <0.61 kat/L (in women).
c
<1.1 kat/L (in men), <0.75 kat/L (in women).
d
0.6–1.8 kat/L.
e
0.1–1.3 kat/L.
f
50–90 μmol/L (women), 60–100 μmol/L (men).