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VT-1161 suppresses parasitemia in mice infected with T. cruzi. Groups of Swiss female mice (n = 6) were infected i.p. with 104 blood trypomastigotes of the Y strain of T. cruzi and not treated (control) or treated with 0.5% carboxymethyl cellulose (vehicle) or 50 mg/kg of VT-1161. The treatment was started on day 5 after infection and performed by oral gavage. The bars represent means ± SEs. Three days of treatment with VT-1161 caused >99.8% suppression of parasitemia.
