TABLE 2.
VT-1161-contacting residues in T. cruzi CYP51 and the corresponding residues in the aligned CYP51 orthologs from two opportunistic fungal pathogens, C. albicans (yeast) and A. fumigatus
| Secondary structural element | Residuea |
|||
|---|---|---|---|---|
| T. cruzi | C. albicans |
A. fumigatusb |
||
| A | B | |||
| A′ helix | F48 | Y64 | Y53 | Y68 |
| B′ helix | Y103 | Y118 | Y107 | Y122 |
| M106 | T122 | T111 | T126 | |
| F110 | F126 | F115 | F130 | |
| B′C loop | Y116 | Y132 | Y121 | Y136 |
| F″ helix | P210 | P230 | P216 | P231 |
| V213 | F233 | F219 | F234 | |
| F214 | V234 | M220 | M235 | |
| I helix | A287 | G303 | T289 | A303 |
| A288 | I304 | L290 | L304 | |
| F290 | M306 | M292 | M306 | |
| A291 | G307 | A293 | A307 | |
| G292 | G308 | G294 | G308 | |
| T295 | T311 | S297 | S311 | |
| K/β1-4 loop | L356 | L376 | I364 | I373 |
| L357 | H377 | H365 | H374 | |
| M358 | S378 | S366 | S375 | |
| β1-4 strand | M360 | F380 | M368 | I377 |
| β4 hairpin | M460 | M508 | L494 | L503 |
a
Boldfacing is explained in the last paragraph of Results.
b
The filamentous fungus A. fumigatus has two CYP51 genes, A and B (24).