FIG 3.
Model-based predicted concentration-time profiles for six individuals. The Dutch Children's Formulary (37), British National Formulary for Children (BNFc) (38), Infectious Diseases Society of America (IDSA) (39), and NeoFax (meningitis regimen) (40; see also Table S1 in the supplemental material) dosing guidelines and model-based dosing algorithms (Table 2) were used. GA, gestational age; PNA, postnatal age; cBW, current body weight. The dotted lines indicate the target concentrations (10 to 15 mg/liter for trough concentrations upon intermittent dosing and 15 to 25 mg/liter for steady-state concentrations upon continuous dosing) and concentrations above which toxicity might occur (40 mg/liter). Concentrations outside the target and peak concentrations above 40 mg/liter are indicated by black dots. AUC24h, calculated area under the concentration-time curve (mg · h/liter) on the seventh day of treatment.