TABLE 2.

Proposed model-based vancomycin dosing algorithms for the neonatal and pediatric populations^a

Clinical characteristic			Intermittent-dosing regimen			Continuous-dosing regimen
PNAb (days)	bBW (g)c	cBW (kg)d	Loading dose (mg/kg)e,f	Maintenance dose (mg/kg/day) (no. of doses)f	AUC24 (mg · h/liter)g	Loading dose (mg/kg)	Maintenance dose (mg/kg/day)h	AUC24 (mg · h/liter)
0–7	≤700		16	15 (3)	264–301	10.5	25	440–502
	700–1,000			21 (3)	332–450		25	395–536
	1,000–1,500			27 (3)	349–490		27	349–484
	1,500–2,500			30 (4)	339–530		30	339–530
	>2,500			36 (4)	354–482		36	354–482
8–14	≤700		20	21 (3)	331–590	10.5	25	394–703
	700–1,000			27 (3)	341–475		32	404–563
	1,000–1,500			36 (3)	390–610		36	390–610
	1,500–2,500			40 (4)	380–504		40	380–504
	>2,500			48 (4)	390–633		48	390–633
14–28	≤700		23i	24 (3)	337–444	10.5	30	421–556
	700–1,000			42 (3)	407–610		42	407–610
	1,000–1,500			45 (3)	385–571		45	385–571
	1,500–2,500			52 (4)	311–657		52	311–657
	>2,500			60 (4)	357–572		60	357–572
>28		<2.5	18	32 (4)	385–471	13	32	385–471
		2.5–5.0	24	40 (4)	385–468		40	385–468
		5.0–10.0	27	52 (4)	434–500		52	434–500
		>10.0	30	60 (4)	463–502		60	463–502

^aThis dosing algorithm (mg/kg current bodyweight) is based on a target AUC₂₄/MIC of >400.

^bPNA, postnatal age.

^cbBW: birth body weight.

^dcBW, current body weight.

^eThe maximum loading dose is 1,200 mg.

^fIf ibuprofen is given and PNA is <28 days, decrease the dose by 2 mg/kg/dose.

^gAUC₂₄ is the noncompartmental calculated area under the concentration-time curve over 24 h. Values are the expected daily AUC range for the different dosing groups.

^hIf ibuprofen is given and the PNA is <28 days, decrease the maintenance dose by 6 mg/kg/day.

ⁱThe loading dose is 26 mg/kg if the PNA is 21 to 28 days.