TABLE 3.
Expected AUC24 at 24h after start of treatment upon intermittent dosing without and with the proposed loading dose
| Individual no. | Agea | Expected AUC24 (mg · h/liter)b |
|
|---|---|---|---|
| Without loading dose | With loading dose | ||
| 1 | GA, 24 weeks; PNA, 14 days | 233 | 411 |
| 2 | GA, 34 weeks; PNA, 14 days | 337 | 440 |
| 3 | GA, 40 weeks; PNA, 14 days | 362 | 436 |
| 4 | PNA, 6 mo | 344 | 457 |
| 5 | PNA, 4 yr | 358 | 466 |
| 6 | PNA, 12 yr | 351 | 433 |
a
GA, gestational age; PNA, postnatal age.
b
AUC24, calculated area under the concentration-time curve over 24 h.