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Effects of neomycin on S. aureus RNase P-mediated ptRNATyr processing. The mobility of precursor tRNATyr in the presence (+) and absence (−) of S. aureus RNase P enzyme and the indicated concentration of neomycin (in micromolar) is shown. Densitometry measured percent activity shown (tRNA product formed) normalized to the value for DMSO-treated enzyme alone.
