TABLE 7.
In vitro activity of paritaprevir and ombitasvir in HCV GT1b-Con1 replicon
| Variant(s) | Fold resistance relative to that of the wild type for: |
Replication efficiency (%) | |
|---|---|---|---|
| Paritaprevir | Ombitasvir | ||
| NS3 | |||
| Y56H | ND | <0.5 | |
| D168A | 27 | 69 | |
| D168E | 4 | 80 | |
| D168V | 159 | 157 | |
| Y56H + D168A | 700 | 6 | |
| Y56H + D168V | 2,472 | 22 | |
| NS5A | |||
| L28M | 2 | 114 | |
| R30Q | 0.4 | 44 | |
| L31F | 10 | 127 | |
| L31M | 0.9 | 119 | |
| L31V | 8 | 86 | |
| P58S | 0.8 | 80 | |
| A92E | 0.7 | 29 | |
| Y93H | 77 | 73 | |
| Y93S | 12 | 23 | |
| L31F + A92E | 1,022 | 36 | |
| L28M + Y93H | 415 | 104 | |
| R30Q + Y93H | 284 | 60 | |
| L31M + Y93H | 142 | 11 | |
| L31V + Y93H | 12,328 | 24 | |
| P58S + Y93H | 1,401 | 34 | |
| L28M + R30Q | 0.5 | 28 | |
| L28M + R30Q + Y93H | 981 | 28 | |
a
ND, not determined due to the poor replication capacity of the variant.