TABLE 3.

Amino acid substitutions in succinate dehydrogenase and susceptibilities of spontaneous ME1111-resistant T. mentagrophytes mutants selected in vitro

Strain(s)	Amino acid substitutiona			MIC (μg/ml)
	SdhB	SdhC	SdhD	ME1111	Carboxin	Boscalid
ATCC 18748 (parent strain)				0.5	32	1
M13	Pro187Ser	—	—	4	128	2
M8, M9	His234Leu	—	—	8	256	>64
M11	His234Tyr	—	—	4	128	>64
M5, M14	Asn238Lys	—	—	4	32	1–2
M10	Gly250Arg	—	—	4	32	1
M1, M2	—	Thr83Asn	—	8	128	8
M3, M17	—	Thr83Ile	—	4	64	8
M7, M16	—	Ser88Gly	—	4	16	1
M15	—	Asn90Lys	—	4	256	>64
M4, M6	—	—	Asp161His	4	128	4
M12	—	—	Tyr162Cys	16	32	4

^a—, amino acid sequence identical to that of the parent strain.