TABLE 1.
Experimental design
| Treatment regimen by mouse strain | No. of mice intended to be killed at time pointa: |
|||||
|---|---|---|---|---|---|---|
| W-6 | D0 | M2 | M3 + 3 | M4.5 + 3 | M6 + 3 | |
| C3HeB/FeJ | ||||||
| 2RHE/4RH | 6 | 10 | 10 | 20 | 30 | 30 |
| 2RHEZ/4RH | 10 | 20 | 30 | 30 | ||
| 2RHEZ/4RHZ | 30 | 30 | ||||
| Total (n = 256) | 6 | 10 | 20 | 40 | 90 | 90 |
| BALB/c | ||||||
| 2RHE/4RH | 3 | 5 | 5 | 15 | 15 | 15 |
| 2RHEZ/4RH | 5 | 15 | 15 | |||
| 2RHEZ/4RHZ | 15 | |||||
| Total (n = 108) | 3 | 5 | 10 | 45 | 30 | 15 |
a
W-6, time of M. tuberculosis infection; D0, start of treatment; M2, 2 months after the start of treatment; M3 + 3, relapse assessment 3 months after 3 months of treatment; M4.5 + 3, relapse assessment 3 months after 4.5 months of treatment; M6 + 3, relapse assessment 3 months after 6 months of treatment.