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. 2016 Jan 29;60(2):789–796. doi: 10.1128/AAC.02465-15

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Copyright © 2016 Linkevicius et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Location of tigecycline resistance mutations in Tet(A): hydrophobic putative transmembrane (TM) regions (pink), completely amphiphilic putative TM regions (light blue), and partially amphiphilic putative TM regions (light green) are indicated. Mutations mentioned in the text are marked in black. Prediction of tertiary structure was performed using online protein homology/analogy recognition engine V 2.0 (Phyre2; http://www.sbg.bio.ic.ac.uk/phyre2/html/page.cgi?id=index) with the intensive modeling mode.