FIG 3.

In vitro Hst-5 release testing from HPMC gel. Percent release of Hst-5 from the gel was assessed at 37°C using a vertical diffusion cell over a 2-h time period, and evaluation of cumulative release of Hst-5 indicated that at 1 h, 85% of Hst-5 is released from the gel (A) with a maximum concentration of 8 μg/ml occurring at 0.5 h (B). (C) Assessment of viscosity of the Hst-5 gel at different temperatures indicated that viscosity decreases with increasing temperature.