TABLE 3.
HCV NI intracellular activation in PC-3 cells
| Base | HCV NI | Mean TP concn (pmol/million) ± SDa |
|---|---|---|
| Uridine | Sofobuvir | 84.7 ± 0.4 |
| Guanosine | IDX184 | 28 ± 2 |
| BMS-986094 | 1,050 ± 30 | |
| PSI-938 | 0.86 ± 0.32 | |
| Cytidine | PSI-6130 | 71 ± 9 |
| 4′-AzidoC | 10 ± 1 | |
| 2′CMeC | 83 ± 7 | |
| Adenosine | GS-6620 | BLQ |
a
The amount of nucleoside triphosphate was determined from three independent LC-MS/MS analyses. The reported TP levels are the maximal concentration observed after 48 h during a 5-day incubation. BLQ, below the limit of quantification.