TABLE 4.
Cocarriage of metallo-β-lactamases and serine β-lactamases in Enterobacteriaceae and P. aeruginosa collected from 2012 to 2014a
| MBL and serine β-lactamase | Organism | No. of isolates | Molecular variant(s) |
|---|---|---|---|
| MBL + KPC | K. pneumoniae | 1 | VIM-1, KPC-2 |
| MBL + KPC + ESBL + AmpC + OSBLb | K. pneumoniae | 2 | VIM-1, KPC-2, SHV-12, CMY-13, TEM-OSBL |
| MBL + KPC + ESBL | K. oxytoca | 2 | IMP-4, KPC-2, SHV-12 |
| MBL + KPC + AmpC | P. aeruginosac | 1 | VIM-2, KPC-2 |
| MBL + KPC + AmpC + OSBL | K. pneumoniae | 1 | VIM-1, KPC-2, MOX-1, SHV-OSBL |
| MBL + OXA carbapenemase + ESBL + AmpC + OSBL | E. cloacaec | 1 | VIM-4, OXA-48, SHV-12, CMY-4, TEM-OSBL |
| MBL + OXA carbapenemase + ESBL + OSBL | K. pneumoniae | 3 | NDM-1, OXA-48, CTX-M-15, SHV-OSBL |
| MBL + OXA carbapenemase + AmpC | E. cloacaec | 1 | VIM-4, OXA-48, CMY-4 |
| 1 | VIM-31, OXA-48 | ||
| MBL + OXA carbapenemase + OSBL | K. pneumoniae | 1 | NDM-1, OXA-232, SHV-OSBL |
| MBL + ESBL + AmpC ± OSBL | C. freundiic | 1 | IMP-8, SHV-12, TEM-OSBL |
| 2 | VIM-1, SHV-12 | ||
| 1 | VIM-4, CTX-M-15, TEM-OSBL | ||
| 1 | NDM-1, CTX-M-3, SHV-12, TEM-OSBL | ||
| E. asburiaec | 1 | IMP-8, SHV-12, TEM-OSBL | |
| 1 | NDM-1, VEB-1, TEM-OSBL | ||
| E. cloacaec | 1 | IMP-8, SHV-12, TEM-OSBL | |
| 1 | IMP-8, CTX-M-22, TEM-OSBL | ||
| 1 | VIM-1, CTX-M-14, TEM-OSBL | ||
| 1 | NDM-1, CTX-M-15 | ||
| 4 | NDM-1, CTX-M-15, TEM-OSBL | ||
| 2 | NDM-1, CTX-M-15, SHV-31, TEM-OSBL | ||
| K. oxytocad | 1 | VIM-1, ACC-1 | |
| 1 | NDM-1, ACC-1, TEM-OSBL | ||
| K. pneumoniae | 1 | IMP-26, CTX-M-15, DHA-1, SHV-OSBL, TEM-OSBL | |
| 1 | NDM-1, CTX-M-15, CMY-6, SHV-OSBL, TEM-OSBL | ||
| 1 | NDM-1, CTX-M-15, CMY-6, DHA-type, SHV-OSBL, TEM-OSBL | ||
| P. stuartiic | 1 | VIM-1, SHV-5, TEM-OSBL | |
| 3 | VIM-1, SHV-5, VEB-1, TEM-OSBL | ||
| S. marcescensc | 2 | NDM-1, CTX-M-15, TEM-OSBL | |
| P. aeruginosac | 1 | VIM-2, SHV-2A | |
| 2 | VIM-2, SHV-12 | ||
| 1 | VIM-2, GES-1 | ||
| 4 | VIM-2, PER-1 | ||
| 1 | VIM-2, VEB-1b | ||
| 1 | VIM-2, VEB-1 | ||
| 1 | VIM-4, SHV-12 | ||
| 1 | VIM-5, PER-1 | ||
| 2 | VIM-5, VEB-14e | ||
| 2 | VIM-45, VEB-1bf | ||
| 2 | NDM-1, VEB-1a | ||
| MBL + ESBL ± OSBL | E. coli | 1 | NDM-1, CTX-M-3 |
| 1 | NDM-1, CTX-M-27 | ||
| K. oxytocad | 1 | IMP-4f | |
| 2 | VIM-1 | ||
| K. pneumoniae | 1 | IMP-1, CTX-M-3, SHV-OSBL | |
| 2 | IMP-4, CTX-M-15, SHV-OSBL | ||
| 1 | IMP-4, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 1 | IMP-26, CTX-M-15, SHV-28 | ||
| 1 | IMP-26, CTX-M-15, SHV-OSBL | ||
| 1 | IMP-26, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 2 | VIM-1, SHV-12 | ||
| 2 | VIM-4, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 1 | VIM-26, SHV-5 | ||
| 1 | VIM-42, SHV-12 | ||
| 1 | NDM-1, CTX-M-15 | ||
| 9 | NDM-1, CTX-M-15, SHV-OSBL | ||
| 16 | NDM-1, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 1 | NDM-1, CTX-M-15, SHV-12 | ||
| 1 | NDM-1, CTX-M-15, SHV-12, TEM-OSBL | ||
| 1 | NDM-1, CTX-M-15, SHV-55, TEM-OSBL | ||
| 1 | NDM-1, CTX-M-15, SHV-134, TEM-OSBL | ||
| 1 | NDM-1, CTX-M-15, CTX-M-27, TEM-OSBL | ||
| 1 | NDM-5, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 2 | NDM-7, CTX-M-15, SHV-12, TEM-OSBL | ||
| 1 | NDM-16, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 1 | NDM-16, CTX-M-15, SHV-12, TEM-OSBL | ||
| P. mirabilis | 1 | VIM-1, SHV-5, VEB-1, TEM-OSBL | |
| 1 | VIM-1, VEB-1, TEM-OSBL | ||
| MBL + AmpC ± OSBL | C. freundiic | 2 | IMP-8, TEM-OSBL |
| 1 | VIM-1 | ||
| 1 | VIM-23 | ||
| 1 | VIM-32 | ||
| 1 | NDM-7, DHA-1 | ||
| 1 | NDM-7, TEM-OSBL | ||
| E. aerogenesc | 1 | VIM-23 | |
| E. asburiaec | 1 | IMP-14 | |
| 1 | NDM-7 | ||
| E. cloacaec | 2 | IMP-1 | |
| 1 | IMP-4 | ||
| 6 | VIM-1 | ||
| 7 | VIM-1, TEM-OSBL | ||
| 2 | VIM-23 | ||
| 2 | NDM-1, DHA-1, TEM-OSBL | ||
| 1 | NDM-7 | ||
| E. coli | 1 | VIM-1, ACT-24, TEM-OSBL | |
| 1 | NDM-5, CMY-42 | ||
| 1 | NDM-5, CMY-42, TEM-OSBL | ||
| P. mirabilis | 1 | IMP-26, DHA-1 | |
| 2 | VIM-1, CMY-16, TEM-OSBL | ||
| P. rettgeric | 1 | NDM-1, TEM-OSBL | |
| P. stuartiic | 1 | VIM-1, CMY-2 | |
| S. marcescensc | 1 | IMP-47, TEM-OSBL | |
| 1 | VIM-4 | ||
| 1 | VIM-5 | ||
| P. aeruginosac | 6 | IMP-1 | |
| 1 | IMP-1, TEM-OSBL | ||
| 2 | IMP-6 | ||
| 8 | IMP-7 | ||
| 1 | IMP-13 | ||
| 1 | IMP-14 | ||
| 1 | IMP-16 | ||
| 2 | IMP-18 | ||
| 1 | IMP-19 | ||
| 5 | IMP-26 | ||
| 6 | IMP-48 | ||
| 1 | IMP-49 | ||
| 6 | VIM-1 | ||
| 228 | VIM-2 | ||
| 1 | VIM-2, TEM-OSBL | ||
| 11 | VIM-4 | ||
| 2 | VIM-5 | ||
| 1 | VIM-6 | ||
| 2 | VIM-28 | ||
| 1 | VIM-43 | ||
| 1 | VIM-44 | ||
| 1 | NDM-1 | ||
| MBL + OSBL | E. coli | 1 | VIM-1, SHV-OSBL |
| K. pneumoniae | 1 | IMP-1, SHV-OSBL | |
| 1 | IMP-4, SHV-OSBL, TEM-OSBL | ||
| 1 | IMP-4, TEM-OSBL | ||
| 1 | IMP-8, SHV-OSBL | ||
| 8 | VIM-1, SHV-OSBL | ||
| 4 | NDM-1, SHV-OSBL | ||
| 1 | NDM-5, SHV-OSBL |
a
Serine β-lactamases were not detected by PCR in 6 MBL-positive Enterobacteriaceae isolates (1 K. pneumoniae isolate and 5 P. mirabilis isolates).
b
OSBL, original spectrum β-lactamase; includes TEM-1, TEM-2, SHV-1, and SHV-11.
c
Presumed to also carry the intrinsic chromosomally encoded AmpC β-lactamase common to this species.
d
Presumed to also carry the intrinsic chromosomally encoded ESBL common to this species.
e
S. Lahiri (formerly of AstraZeneca Pharmaceuticals), personal communication.
f
The full gene sequence was determined by whole-genome sequencing.