TABLE 1.
Plasma PK parameters of PZA in C3HeB/FeJ micea
| Mice and infection status | PZA dose (mg/kg) | AUC0–24 (μg · h/ml) | Cmax (μg/ml) | T1/2 (h) |
|---|---|---|---|---|
| C3HeB/FeJ | ||||
| Uninfected (single dose) | 10 | 9.2 | 5.6 | 0.6 |
| 30 | 59.2 | 23 | 1 | |
| 150 | 577.9 | 187.8 | 1.4 | |
| 300 | 1,081.6 | 263 | 1.9 | |
| 450 BID | 5,326.8 | 665.3 | 3.5 | |
| Infected (steady state) | 150 | 455.6 | 166 | 1.3 |
| 450 BID | 3,589.6 | 467 | 1.6 | |
| BALB/c mice | ||||
| Infected (single dose) | 150 (30) | 388 | 163 | 1.2 |
| 450 BID (unpublished data) | 3,241.8 | 472.9 | 2.3 |
a
Parameters were calculated from mean concentration data. The data presented are from one of two representative experiments for each infection condition.