TABLE 2.
ELF/plasma PZA concentration ratios in C3HeB/FeJ mice
| Mouse infection status | PZA dose (mg/kg) | Median ELF/plasma ratio (no. of mice) ata: |
|||
|---|---|---|---|---|---|
| 1.5 h | 3 h | 7 h | 12 h | ||
| Uninfected (single dose) | 30 | 1.2 (2) | 3.7 (1) | ||
| 150 | 0.9 (7) | 1 (4) | 22.8 (4) | ||
| 300 | 2 (6) | 1 (5) | |||
| 450 BID | 1.1 (3) | 2.2 (3) | 1.2 (3) | ||
| Infected (steady state) | 150 | 1.1 (6) | 3 (7) | 3.1 (8) | NA |
| 450 BID | 1.3 (6) | 1.6 (8) | 1.2 (7) | ||
a
NA, not applicable (due to a nonquantifiable PZA concentration in ELF or plasma). No PZA was measurable at 0-h and 17-h time points or in the 10-mg/kg arm.