TABLE 2.

Epidemiologic cutoff values of amphotericin B, itraconazole, posaconazole, and voriconazole for two clinically relevant Fusarium species complexes and F. verticillioides as determined by the CLSI broth microdilution method^a

Species or species complex	Antifungal agentb	MIC (μg/ml)		Calculated statistical ECV (μg/ml)c
		Range	Moded	≥95%	≥97.5%	≥99%
F. verticillioides	AMB	0.5–16	2	4	4	4
	ITR	1–≥16	16	ND	ND	ND
	POS	≤0.25–≥16	0.5	2	2	2
	VOR	0.5–≥16	2	4	4	8
F. oxysporum SC	AMB	≤0.25–16	2	4	8	8
	ITR	1–≥16	16	32	32	32
	POS	0.5–16	2	8	8	8
	VOR	0.5–≥16	4	8	16	16
F. solani SC	AMB	≤0.25–16	2	4	8	8
	ITR	0.5–≥16	16	16	32	32
	POS	1–≥16	8	32	32	32
	VOR	0.5–≥16	8	16	32	32

^aECVs were defined for pooled distributions for ≥100 isolates from ≥3 laboratories using the methodology of CLSI document M38-A2 (25, 35).

^bAMB, amphotericin B; ITR, itraconazole; POS, posaconazole; VOR, voriconazole.

^cCalculated ECVs comprising ≥95%, ≥97.5%, and ≥99% of the statistically modeled population. ND, not determined (due to insufficient data).

^dMIC most frequently obtained for each distribution.