Table IV.
Predictors of consultation for a likely ADR.
| Consultation | ||||||
|---|---|---|---|---|---|---|
| At least one likely ADR n = 174 n (%) |
At least one possible ADR* n = 408 n (%) |
At least one unlikely ADR** n = 379 n (%) |
No consultation n = 15 665 n (%) |
OR (95% CI) Likely ADR vs. no consultation |
Adjusted OR†
(95% CI) Likely ADR vs. no consultation |
|
| Age category: | ||||||
| 18–35 36–50 51–65 > 65 |
37 (21.3) 49 (28.2) 36 (20.7) 52 (29.9) |
53 (13.0) 137 (33.6) 108 (26.5) 110 (27.0) |
54 (14.2) 110 (29.0) 110 (29.0) 105 (27.7) |
2 774 (17.7) 5 374 (34.3) 4 854 (31.0) 2 663 (17.0) |
1 (ref.) 0.7 (0.4–1.1) 0.6 (0.4–0.9) 1.5 (1.0–2.2) |
– – – – |
| Gender: | ||||||
| Male Female |
59 (33.9) 115 (66.1) |
131 (32.1) 277 (67.9) |
137 (36.1) 242 (63.9) |
7 349 (46.9) 8 316 (53.1) |
1 (ref.) 1.7 (1.3–2.4) |
– – |
| Type of NSAID: | ||||||
| Non-selective NSAID | 162 (93.1) | 392 (96.1) | 355 (93.7) | 15 132 (96.6) | 1 (ref.) | 1 (ref.) |
| Coxib | 12 (6.9) | 16 (3.9) | 24 (6.3) | 533 (3.4) | 2.1 (1.2–3.8) | 1.9 (1.1–3.5) |
| Concomitant GPA prescribed: | ||||||
| None PPI H2RA in double dosage Misoprostol |
82 (47.1) 67 (38.5) 0 (0.0) 25 (14.4) |
227 (55.6) 142 (34.8) 0 (0.0) 39 (9.6) |
214 (56.5) 135 (35.6) 0 (0.0) 30 (7.9) |
10 071 (64.3) 4 231 (27.0) 3 (0.0) 1 350 (8.7) |
1 (ref.) 1.9 (1.4–2.7) – 2.3 (1.4–3.5) |
1 (ref.) 1.8 (1.3–2.6) – 2.2 (1.4–3.5) |
Notes: ADR = adverse drug reaction; NSAID = non-steroidal anti-inflammatory drug; coxib = selective cox-2 inhibitor;
GPA = gastroprotective agent; PPI = proton pump inhibitor; H2RA = histamine-2 receptor antagonist. *And no likely ADR. **And no likely or possible ADR. †Adjusted for age and gender.