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. 2015 Dec 10;35(3):1255–1264. doi: 10.3892/or.2015.4484

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Sodium selenite treatment inhibits tumor growth, induces apoptosis and autophagy in HCT116 and SW480 xenograft models. (A and B) The images of tumors are shown in the left panel and the weights of tumor are plotted in the right panel. (C and D) The results of sodium selenite treatment on the body weight of mice. (E) Histopathological examination of the tumors and liver with H&E staining in the selenite-treated group and the control group (magnification, ×200). (F) Selenite-treatement regulates the apoptosis and autophagy proteins in vivo. (G) Western blot analysis of the expression of cleaved PARP, cleaved caspase-9, p62, Beclin-1 and LC3 in the HCT116 and SW480 xenograft tumors.

Sodium selenite treatment inhibits tumor growth, induces apoptosis and autophagy in HCT116 and SW480 xenograft models. (A and B) The images of tumors are shown in the left panel and the weights of tumor are plotted in the right panel. (C and D) The results of sodium selenite treatment on the body weight of mice. (E) Histopathological examination of the tumors and liver with H&E staining in the selenite-treated group and the control group (magnification, ×200). (F) Selenite-treatement regulates the apoptosis and autophagy proteins in vivo. (G) Western blot analysis of the expression of cleaved PARP, cleaved caspase-9, p62, Beclin-1 and LC3 in the HCT116 and SW480 xenograft tumors.