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. 2015 Dec 10;35(3):1255–1264. doi: 10.3892/or.2015.4484

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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ROS are involved in the regulation of apoptosis and autophagy in HCT116 and SW480 CRC cells. (A) Cell samples were pretreated with MnTMPyP and H₂O₂ and then treated with selenite for 24 h. Green signal indicates LC3, and nuclei were stained with DAPI solution. Scale bar, 10 µm. (B) Flow cytometry results of the samples from selenite-treated HCT116 and SW480 CRC cells for 24 h with or without MnTMPyP and H₂O₂. (C) Western blot analysis of the expression of cleaved PARP and LC3. (D) Schematic illustration of the crosstalk between selenite-induced autophagy and apoptosis in CRC cells.

ROS are involved in the regulation of apoptosis and autophagy in HCT116 and SW480 CRC cells. (A) Cell samples were pretreated with MnTMPyP and H₂O₂ and then treated with selenite for 24 h. Green signal indicates LC3, and nuclei were stained with DAPI solution. Scale bar, 10 µm. (B) Flow cytometry results of the samples from selenite-treated HCT116 and SW480 CRC cells for 24 h with or without MnTMPyP and H₂O₂. (C) Western blot analysis of the expression of cleaved PARP and LC3. (D) Schematic illustration of the crosstalk between selenite-induced autophagy and apoptosis in CRC cells.