Table 1.
Baseline patient characteristics
| Control (n = 61) | Mild OSAS (n = 67) | Moderate OSAS (n = 61) | Severe OSAS (n = 101) | ANOVA p | |
|---|---|---|---|---|---|
| Age, years | 44.0 ± 15.4 | 48.2 ± 13.4 | 49.1 ± 11.8 | 51.4 ± 12.5* | 0.003 |
| Male, n (%) | 33 (54.1) | 39 (58.2) | 41 (67.2)* | 80 (79.2)* | <0.001 |
| BMI, kg/m2 | 24.2 ± 4.43 | 24.7 ± 3.20 | 26.4 ± 3.58*,+ | 26.9 ± 3.41*,+ | <0.001 |
| SBP, mmHg | 123.4 ± 13.7 | 123.5 ± 13.1 | 128.5 ± 13.6* | 128.2 ± 12.4* | 0.027 |
| DBP, mmHg | 78.4 ± 10.7 | 77.0 ± 8.9 | 80.8 ± 9.2 | 81.2 ± 9.9* | 0.039 |
| Heart rate, /min | 72.6 ± 7.90 | 73.3 ± 10.3 | 76.3 ± 10.5 | 76.7 ± 9.15* | 0.020 |
| Hypertension, n (%) | 5 (8.2) | 13 (19.4) | 18 (29.5)* | 30 (29.7)* | 0.005 |
| Diabetes mellitus, n (%) | 1 (1.6) | 2 (3.0) | 4 (6.6) | 13 (12.9) * | 0.048 |
| Dyslipidemia, n (%) | 2 (3.3) | 2 (3.0) | 3 (4.9) | 3 (3.0) | 0.917 |
| Smoking, n (%) | 6 (9.8) | 14 (20.9) | 12 (19.7) | 18 (17.8) | 0.123 |
| Total cholesterol, mg/dl | 170.0 ± 38.2 | 184.0 ± 34.6 | 190.6 ± 45.6 | 172.4 ± 46.9 | 0.161 |
| TG, mg/dl | 141.1 ± 84.8 | 151.2 ± 8.03 | 160.8 ± 89.1 | 176.1 ± 144.9 | 0.606 |
| FBS, mg/dl | 101.5 ± 17.2 | 92.8 ± 10.3 | 105.8 ± 21.7 | 111.6 ± 45.3 | 0.034 |
| ESR, mm/hr | 7.8 ± 11.6 | 17.9 ± 30.2 | 15.5 ± 15.3 | 14.0 ± 10.9 | 0.224 |
| hs-CRP, mg/L | 0.53 ± 1.32 | 1.14 ± 2.28 | 0.82 ± 1.38 | 1.12 ± 2.08 | 0.529 |
| WBC, x106/L | 6759 ± 1806 | 7283 ± 2031 | 7314 ± 2976 | 7724 ± 2051 | 0.103 |
| Neutrophil, % | 53.1 ± 11.2 | 59.1 ± 11.0 | 55.1 ± 13.8 | 60.5 ± 10.3* | 0.001 |
| Lymphocyte, % | 36.1 ± 9.87 | 33.0 ± 12.8 | 30.0 ± 9.22 | 27.4 ± 8.35* | <0.001 |
| Eosinophil, % | 2.24 ± 1.66 | 3.01 ± 2.03 | 2.60 ± 1.99 | 2.90 ± 2.16 | 0.217 |
| Monocyte, % | 7.91 ± 2.54 | 7.44 ± 2.15 | 8.51 ± 5.96 | 7.35 ± 1.71 | 0.234 |
| RBC, x109/L | 4587 ± 423.9 | 4692 ± 377.2 | 4660 ± 282.4 | 4599 ± 378.1 | 0.286 |
| Hemoglobin, g/dl | 13.5 ± 1.5 | 14.0 ± 1.4 | 13.8 ± 1.6 | 14.4 ± 1.6* | 0.004 |
| Hematocrit, % | 40.2 ± 4.4 | 41.2 ± 4.2 | 40.2 ± 6.6 | 42.5 ± 4.5* | 0.010 |
| RDW, % | 13.5 ± 1.57 | 13.3 ± 1.25 | 13.5 ± 1.05 | 13.3 ± 0.76 | 0.735 |
| Platelet, x109/L | 216.7 ± 54.4 | 224.8 ± 56.0 | 231.3 ± 80.6 | 252.4 ± 66.8* | 0.007 |
| PLR | 99.5 ± 42.1 | 113.8 ± 45.2 | 121.3 ± 62.9* | 138.6 ± 59.9* | 0.001 |
| PDW, % | 15.9 ± 1.12 | 16.3 ± 0.95 | 16.4 ± 0.99* | 16.5 ± 0.82* | 0.003 |
All values are presented as means ± SD. BP, blood pressure; hs-CRP, high sensitivity C-reactive protein; OSAS: obstructive sleep apnea syndrome; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglyceride; FBS, fasting blood sugar; ESR, erythrocyte sedimentation rate; WBC, white blood cell; RBC, white blood cell; RDW, red cell distribution width; PLR, platelet lymphocyte ratio; PDW, platelet volume distribution width, *p < 0.05 vs. control group, + p < 0.05 vs. mild OSAS group