Table 1.

Cu-induced differential expression of miRNAs ranked by p-value ^a.

Cu exposure	miRNA name	FC	p-value	Log2 AE
Cu-L	miR-187	1.80	0.017	9.16
	miR-140*	0.50	0.045	8.80
Cu-M	miR-183	0.48	0.004	8.73
	miR-187	1.87	0.013	9.16
	miR-724	2.23	0.019	9.09
	let-7g	2.04	0.023	6.86
	let-7i	1.98	0.025	9.25
	miR-140*	0.45	0.025	8.80
	miR-214	0.48	0.029	11.51
	miR-458	3.01	0.040	5.75
	miR-126	2.24	0.048	7.51
	miR-7a	4.68	0.049	6.39
Cu-H	miR-31	4.53	0.002	5.13
	miR-203b	2.47	0.002	9.76
	let-7g	2.92	0.002	6.86
	miR-724	3.06	0.003	9.09
	miR-140*	0.34	0.005	8.80
	let-7f	3.10	0.006	7.61
	miR-16a	2.50	0.007	5.98
	let-7i	2.36	0.008	9.25
	miR-214	0.41	0.011	11.51
	miR-183	0.55	0.013	8.73
	miR-128	1.52	0.013	13.24
	miR-458	4.08	0.013	5.75
	miR-25	2.27	0.014	8.22
	miR-126	2.85	0.015	7.51
	miR-187	1.78	0.019	9.16
	let-7e	3.22	0.021	6.64
	miR-199*	2.63	0.022	8.84
	let-7a	1.64	0.023	12.99
	miR-203a	3.91	0.023	5.54
	miR-138	0.60	0.024	12.93
	miR-23a	1.60	0.024	10.10
	miR-146a	5.14	0.029	5.33
	let-7h	1.90	0.030	7.30
	miR-16c	2.03	0.031	7.63
	miR-30c	2.88	0.035	5.34
	miR-27b	1.57	0.036	8.67
	miR-150	1.72	0.045	9.02
	miR-193b	0.36	0.049	10.12

^aData represents only those miRNAs >1.5-fold up-regulated (red), or down-regulated (green) with a statistical significance of p<0.05 and Log₂ average expression >5. Down-regulation is indicated as percent of control. FC=fold-change; AE=average expression.