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. 2016 Feb 15;27(4):617–626. doi: 10.1091/mbc.E15-10-0703

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© 2016 Xiao et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Association of decreased SPRY4-IT1 with reduction in the levels of TJs in patients with gut barrier dysfunction. (A) Levels of SPRY4-IT1 in the intestinal mucosa in patients with increased gut permeability (IGP) or controls (Ctrl) as measured by Q-PCR analysis and normalized to Gapdh levels. Values are means ± SEM (n = 7). *p < 0.05 compared with controls. (B) In situ hybridization of SPRY4-IT1 with fluorescent LNA RNA detection probe in the intestinal mucosa described in A. (C) Immunohistochemical staining of TJ proteins in the intestinal mucosa described in A.