TABLE 1:
Differentially expressed genes enriched for annotated relationships in aNSCs with basal versus depleted Kdm5b activity.
| Up-regulated in: | Gene symbol | Fold ratio | p |
|---|---|---|---|
| Function: steroid metabolism | |||
| shScr | Dhcr24 | 2.09 | <0.001 |
| shScr | Dhcr7 | 2.16 | <0.001 |
| shScr | Fdps | 2.27 | <0.001 |
| shScr | Ldlr | 2.83 | <0.001 |
| shScr | Lss | 3.10 | <0.001 |
| shScr | Mvd | 2.82 | <0.001 |
| shScr | Nsdhl | 2.99 | <0.001 |
| shKdm5b | Sqrl1 | 3.64 | <0.05 |
| shScr | Sqle | 2.00 | <0.001 |
| Function: regulation of transcription | |||
| shKdm5b | Cebpb | 2.14 | <0.05 |
| shScr | Ebf1 | 2.58 | <0.001 |
| shScr | Gtf2a1 | 2.74 | <0.001 |
| shKdm5b | Hmga1 | 2.06 | <0.05 |
| shScr | Irx2 | 3.76 | <0.001 |
| shScr | Mta1 | 2.35 | <0.05 |
| shKdm5b | Relb | 2.29 | <0.05 |
| shKdm5b | Tcea3 | 2.47 | <0.05 |
| Function: cellular transport | |||
| shKdm5b | Cacna2d1 | 2.57 | <0.05 |
| shKdm5b | Cacng5 | 2.70 | <0.05 |
| shKdm5b | Col4a6 | 3.35 | <0.05 |
| shKdm5b | Col6a1 | 22.27 | <0.05 |
| shKdm5b | Copz2 | 2.60 | <0.05 |
| shKdm5b | Ecm1 | 2.35 | <0.05 |
| shKdm5b | Gria1 | 2.08 | <0.05 |
| shKdm5b | Hmga1 | 2.06 | <0.05 |
| shScr | Kcnk13 | 2.84 | <0.001 |
| shKdm5b | Kdelr3 | 2.54 | <0.05 |
| shScr | Ldlr | 2.83 | <0.001 |
| shKdm5b | Rab15 | 2.46 | <0.05 |
| shKdm5b | Rab38 | 2.44 | <0.05 |
| shKdm5b | Rac3 | 2.06 | <0.05 |
| shKdm5b | Rasl11A | 2.31 | <0.05 |
| shKdm5b | Rbp1 | 2.68 | <0.05 |
| shKdm5b | Scara3 | 2.37 | <0.05 |
| shKdm5b | Slc16a6 | 2.47 | <0.05 |
| shScr | Slc2a6 | 2.12 | <0.001 |
| shScr | Slc39a12 | 2.19 | <0.001 |
| shKdm5b | Slc6a17 | 2.24 | <0.05 |
| shKdm5b | Sorl1 | 3.64 | <0.05 |
| shKdm5b | Syt4 | 8.91 | <0.05 |
| shScr | Wnk1 | 2.08 | <0.001 |
| Function: response to immune stimulus | |||
| shKdm5b | Anxa11 | 2.06 | <0.05 |
| shScr | C2 | 2.47 | <0.001 |
| shKdm5b | Ccl7 | 4.61 | <0.05 |
| shKdm5b | Cebpb | 2.14 | <0.05 |
| shKdm5b | Cxcl10 | 3.93 | <0.05 |
| shKdm5b | Gbp2 | 2.52 | <0.05 |
| shKdm5b | Hspb1 | 2.23 | <0.05 |
| shKdm5b | Hspb8 | 2.25 | <0.05 |
| shKdm5b | Psmb9 | 2.01 | <0.05 |
| shKdm5b | Scara3 | 2.37 | <0.05 |
| shKdm5b | Tap1 | 2.41 | <0.05 |
| shKdm5b | Tlr2 | 3.95 | <0.05 |
Subsets of genes are shown from the complete differentially expressed set that are significantly (p < 0.05) supported with a cluster of associations for an annotated relationship or function. Individual differentially expressed genes associated with an annotation are listed with the condition for up-regulated expression, the fold ratio of expression, and p for statistical test of sample expression values compared with the other condition.