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. 2016 Feb 11;11(2):e0148709. doi: 10.1371/journal.pone.0148709

Fig 5. Effects of experimentally induced mitochondrial dysfunction on GDF-15 mRNA expression and GDF15 protein release in muscle cells.

Fig 5

GDF15 mRNA and FGF21 mRNA levels in C2C12 myotubes (A) or LHCN myotubes (B), and correlation between GDF-15 mRNA levels and FGF21 mRNA levels (C) in the experimental settings in C2C12 cells (up) and LHCN cells (down). GDF-15 protein concentrations in C2C12 cell culture medium (D). Bars are means ±S.E.M. from 4–6 independent experiments. *p <0.05, **p <0.01, ***p <0.001, relative to untreated controls. # p <0.05, relative to corresponding condition non-treated with Trolox. R and P values are shown in the correlation panel C.