Table 2. Diagnostic performance of GDF-15 (A) and FGF-21 (B) for a cut-off value of 550pg/ml and 300pg/ml respectively.

95% confidence intervals are indicated in brackets.

GDF-15
Group	Sensitivity	Specificity	PPV	NPV
All	67.8%(54.4%–79.4%)	92.3%(81.5%–97.9%)	93% (80.9%–98.5%)	61.2% (46.2%–74.8%)
Confirmed	72.7% (49.8%–89.2%)	92.3% (81.5%–97.9%)	84.2%(60.4%–96.6%)	83.3%(67.2%–93.6%)
Definitive	70% (45.7%–88.1%)	92.3% (81.5%–97.9%)	82.3%(56.7%–96.2%)	83.3%(67.2%–93.6%)
Probable	58.8%(32.9%–81.6%)	92.3% (81.5%–97.9%)	76.9%(46.2%–94.9%)	81.1% (64.8%–92%)
FGF-21
Group	Sensitivity	Specificity	PPV	NPV
All	52.5% (39.1%–65.7%)	96.2%(87%–99.5%)	100% (89.4%–100%)	56.7% (43.2%–69.4%)
Confirmed	59.1% (36.3% to 79.3%)	96.2%(87%–99.5%)	100% (78.2%–100%)	82.9% (67.9%–92.8%)
Definitive	60%(36.1%–80.9%)	96.2%(87%–99.5%)	100% (73.5%–100%)	80.9%(56.9%–91.4%)
Probable	35.3% (14.2%–61.7%)	96.2%(87%–99.5%)	100% (54.1%–100%)	75.6% (60.5%–87.1%)