. Author manuscript; available in PMC: 2017 Mar 1.

Published in final edited form as: Paediatr Perinat Epidemiol. 2015 Dec 3;30(2):181–189. doi: 10.1111/ppe.12261

Table 2.

Maternal C-reactive protein (CRP) levels in early pregnancy and Social Responsiveness Scale scores in children at the age of 6 years. The Generation R Study.

Social Responsiveness Scale
	Model 1¹	Model 2²	Model 3³	Model 4⁴	Model 5⁵

CRP mg/L	B (95% CI)	B (95% CI)	B (95% CI)	B (95% CI)	B (95% CI)
Continuous⁶	0.009 (0.003, 0.015)	0.005 (0.000, 0.011)	0.005 (0.000, 0.011)	0.004 (−0.002, 0.009)	0.004 (−0.002, 0.009)
≤2.3	Reference	Reference	Reference	Reference	Reference
2.4-4.3	0.008 (−0.013, 0.030)	0.003 (−0.017, 0.024)	0.001 (−0.020, 0.022)	−0.001 (−0.022, 0.021)	0.000 (−0.021, 0.021)
4.4-7.8	0.030 (0.008, 0.052)	0.014 (−0.007, 0.035)	0.013 (−0.008, 0.035)	0.008 (−0.013, 0.030)	0.008 (−0.014, 0.030)
>7.8	0.055 (0.033, 0.078)	0.029 (0.008, 0.051)	0.028 (−0.006, 0.050)	0.019 (−0.005, 0.042)	0.018 (−0.005, 0.042)

Basic model adjusted for children's age at the time of assessment and gender.

Additionally adjusted for maternal age, maternal educational levels, maternal ethnic background, marital status, maternal history of smoking and maternal psychopathology in pregnancy.

Additionally adjusted for paternal age, paternal educational levels and household income.

⁴

Additionally adjusted for parity, time of blood sampling during pregnancy and maternal body mass index.

⁵

Additionally adjusted for children's gestational age, birthweight and breast feeding at 6 months.

⁶

The values for continuous CRP concentrations were divided by standard deviation in the sample.

The B's are not interpretable since the mathematically transformed scores were used in the analyses.