Table 3.
Maternal C-reactive protein (CRP) levels in early pregnancy and Pervasive Developmental Problems in children at the age of 6 years. The Generation R Study.
| Pervasive Developmental Problems In the Clinical Range | |||||
|---|---|---|---|---|---|
| Model 11 | Model 22 | Model 33 | Model 44 | Model 55 | |
| CRP mg/L | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| Continuous6 | 1.0 (0.9, 1.2) | 1.4 (0.9, 1.2) | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.2) |
| ≤2.3 | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) |
| 2.4-4.3 | 0.9 (0.6, 1.1) | 0.8 (0.4, 1.4) | 0.8 (0.4, 1.4) | 0.7 (0.4, 1.4) | 0.8 (0.4, 1.4) |
| 4.4-7.8 | 1.3 (0.8, 2.3) | 1.2 (0.7, 2.1) | 1.2 (0.7, 2.1) | 1.1 (0.7, 2.0) | 1.1 (0.6, 2.0) |
| >7.8 | 1.7 (1.1, 2.8) | 1.5 (0.9, 2.6) | 1.5 (0.9, 2.6) | 1.4 (0.8, 2.4) | 1.4 (0.8, 2.4) |
Pervasive Developmental Problems in the Clinical Range were defined as scores above the 98th percentile of a Dutch norm population
Basic model adjusted for children's age at the time of assessment and gender.
Additionally adjusted for maternal age, maternal educational levels, maternal ethnic background, marital status, maternal history of smoking and maternal psychopathology in pregnancy.
Additionally adjusted for paternal age, paternal educational levels and household income.
Additionally adjusted for parity, time of blood sampling during pregnancy and maternal body mass index.
Additionally adjusted for children's gestational age, birthweight and breast feeding at 6 months.
The values for continuous CRP concentrations were divided by standard deviation in the sample.
Pervasive developmental problems were defined as the scores in the highest 2% of the Child Behavior Checklist pervasive developmental problems scale (n=119)