Table II.

Comparing fatigue and neurotrophic factors during EBRT.

	EBRT patients
	Baseline (N = 47)		Midpoint of EBRT (N = 47)		Wilcoxon Sign Rank Test
Proteins	Mean ± SE	Median	Mean ± SE	Median	Z	P value	Effect size (r)
Fatigue score (FACT-F)	43.95 ± 1.28	47.00	38.36 ± 1.52	39.50	−3.590	0.000	0.37
Glial cell derived neurotrophic factor (GDNF) (ng/mL)	2.01 ± 1.22	0.13	1.49 ± 0.80	0.13	−1.18	0.24	0.12
Brain derived neurotrophic factor (BDNF) (ng/mL)	1.10 ± 0.12	0.86	0.84 ± 0.10	0.82	−2.30	0.02*	0.24
SNARE-associated protein (SNAPIN) (pg/mL)	34.95 ± 7.33	20.29	34.95 ± 8.72	20.13	−0.01	0.99	0.00

Levels of fatigue as measured by the Functional Assessment of Cancer Therapy-Fatigue (FACT-F) scale and plasma concentrations of neurotrophic factors measured in ng/mL during external beam radiation therapy (EBRT) are presented as mean with standard error (SE) and median.

Changes in fatigue and neurotrophic factors are indicated by standard scores or z scores, and significant difference between time points indicated by * P < 0.05 and effect size (r).