. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Am J Clin Oncol. 2018 Jan;41(1):24–29. doi: 10.1097/COC.0000000000000221

Table 5. Survival and Prognostic Factors in Literature Series.

Negative Prognostic Factors^α	Schrevens et al.	Fink et al.	Harpole et al.	Filosso et al.	Garcia-Yuste et al.	Tsuta et al.	Our Study
Atypical Histology	Yes P=0.02 HR=0.22^β	Yes P<0.05	Yes P<0.001	Yes P=0.0004	Yes P=0.0001	Yes P<0.0001	Yes P=0.031
Tumor Size	No P=0.57	-	Yes P<0.001	-	-	-	No P=0.97
LN Involvement	Yes P=0.0009 HR=0.13	-	Yes P<0.001	Yes P=0.21	-	-	Yes P<0.001
Pathologic Stage	-	-	Yes P<0.01	-	-	Yes P=0.04	-
Symptomatic Presentation	-	-	Yes P<0.01	-	-	-	No P=0.36
Older Age^δ	-	-	No P>0.1	-	-	Yes P=0.002	No P>0.05

^α

P-value: Comparison between subgroups according to log-rank statistic;

^β

Only study to report hazard ratio;

^δ

<60 vs. ≥60 years