Skip to main content
. 2016 Feb 11;11(2):e0149113. doi: 10.1371/journal.pone.0149113

Fig 2. Structural analysis of the interaction between HD-PTP and STAM2.

Fig 2

(A) Crystal structure of the HD-PTP(1–361;NAYA)−STAM2(350–370) complex. (Left) The two proteins are presented as ribbon drawings with the labels of secondary structures according to the order of their appearance in the primary sequence. (Right) α-helical wheel representation of the STAM2 fragment shown in the complex structure. STAM2 residues in contact with those of HD-PTP within 4 Å are covered by a gray semicircle. (B-C) Intermolecular hydrophobic interaction (B) and water-mediated hydrogen bonds (C). Shown in sticks are all STAM2 residues together with the HD-PTP residues involved in the complex formation step. Hydrogen bonds mediated by three water molecules (shown in red sphere) are represented as dotted lines. Labeled are the two protein residues participating in the intermolecular interaction.