Table 1.
Prevalence studies of thyroid antibodies in patients with mood disorders
| Authors | Antibody | Bipolar disorder | Major depression | Other | Normal controls |
|---|---|---|---|---|---|
| Gold et al. (1982) | AbM | – | – | Hospitalized for depression or lack of energy 9/100 (9 %) | – |
| Nemeroff et al. (1985) | AbM and/or AbTG | 0/3 (0 %) | 7/28 (25 %) | Any hospitalized with prominent depressive symptoms 9/45 (20 %) | – |
| Joffe (1987) | AbM and/or AbTG | – | 5/58 (8.6 %) | – | – |
| Haggerty et al. (1990) | AbM and/or AbTG | 4/31 (13 %) | 5/65 (8 %) | Non-affective disorders 7/68 (10 %) | – |
| Custro et al. (1994) | AbTPO and/or AbTG | – | 5/9 (56 %) | Minor depression 0/66 (0 %) | 1/38 (3 %) |
| Haggerty et al. (1997) | AbM and/or AbTG | Mixed 5/26 (19 %) Depressed 3/19 (16 %) Manic 2/51 (3.9 %) |
15/218 (6.9 %) | Adjustment disorder 2/80 (2.5 %) | 10/144 (6.9 %) |
| König et al. (1999) | AbTPO or AbM and/or AbTG | – | Severe, hospitalized 100/144 (70 %) | – | – |
| Kupka et al. (2002) | AbTPO | 64/226 (28.3 %) | – | Any psychiatric hospitalization 324/3190 (10.2 %) | 23–34/252 (9.1–13.5 %) range with different assays |
| Brouwer et al. (2005) | AbTPO | – | Outpatients 9/113 (8 %) | – | 11/113 (10 %) |
| Degner et al. (2015) | AbTPO and/or AbTG | 4/13 (30.8 %) | 12/39 (38.5 %) | Schizophrenia 2/19 (10.5 %) | – |