Table 3.
Case reports of autoimmune thyroiditis associated with mood disorder
| Authors | Presentation | Sex and age | TSH (µU/ml) | Antibody titer (normal range) | Treatment |
|---|---|---|---|---|---|
| Schmidt et al. (1990) | Menstrual related mood disorder | F 37 | 12.1 | AbM 1/1600 (<1/100) AbTG 1/10 (<1/10) |
Levothyroxine |
| Bokhari et al. (1998) | Postpartum psychosis | F 29 | <0.03 | AbTPO 2330 (0–100) AbTG 597 (0–100) |
Loxapine, amoxapine, propranolol, propylthiouracil |
| Mahmud et al. (2003) | Psychotic depression | F 14 | 77.4 | AbTPO 6320 (0–20) | Psychotropic medication as before (valproate, sertraline, quetiapine) plus levothyroxine, methylprednisolone |
| Müssig et al. (2005) | Manic episode | F 32 | <0.03 | AbTPO 2010 (0–2) AbTG 1.1 (0–1) |
Psychotropic medication as before (quetiapine, lithium, mirtazapine, venlafaxine) plus reboxetine and transcranial magnetic stimulation, carbimazole, prednisolone |
| Laske et al. (2005) | Severe depressive episode | F 74 | Normal | AbTPO 842 (0–2) | Prednisolone, venlafaxine as before |
| Stowell and Barnhill (2005) | Postpartum psychotic acute mania | F 35 | >150 | AbTPO significantly elevated | Levothyroxine and risperidone |
| Tor et al. (2007) | Late-onset psychotic mania | F 72 | 79.4 | AbTPO 50 (0–50) AbTG 2507 IU/ml (0–40) |
Levothyroxine and low-dose haloperidol |
| Bocchetta et al. (2007b) | Affective psychosis | F 43 | 1.24 | AbTPO>1000 (0–35) AbTG normal |
Levothyroxine as before, valproate discontinuation, lithium plus olanzapine |
| Nagamine et al. (2008) | Lithium-induced encephalopathy | F 61 | 2.15 | AbTPO 50 (0–0.3) AbTG 1/25,600 (1/100) |
Methylprednisolone, levothyroxine as before, lithium discontinuation |
| Liu et al. (2011) | Acute depressive episode | M 46 | 66.7 | AbTPO 1698 (0–5.61) AbTG 154 IU/ml (0–14.4) |
Levothyroxine, methylprednisolone |
| Lin et al. (2011) | Manic symptoms | F 52 | 50.71 | AbTPO 1652 (0–25) AbTG 296 IU/ml (0–25) |
Levothyroxine, prednisolone, olanzapine and valproate |
| Lin et al. (2013) | Acute mania | F 41 | 18.79 | AbTPO 411 (0–60) AbTG 296 IU/ml (0–60) |
Levothyroxine, valproate and quetiapine |