TABLE 5.
Genomic diversity of LOS biosynthetic genes in N. meningitidis
Total number of strains in each column is as follows: unique alleles all strains (32,202), carrier (6596), meningitis (3252), septicemia (958), meningitis and septicemia (669), and invasive not specified (16,686).
| Locusa | Unique alleles | Carrier | Meningitis | Septicemia | Meningitis and septicemia | Invasive not specified |
|---|---|---|---|---|---|---|
| ADP-heptose biosynthesis | ||||||
| NEIS0769 (hldA) | 108 | 30 | 6 | 2 | 2 | 86 |
| NEIS0773 (hldD) | 145 | 42 | 14 | 3 | 4 | 115 |
| NEIS2014 (gmhB) | 85 | 31 | 9 | 3 | 5 | 65 |
| NEIS2055 (hldC) | 82 | 30 | 10 | 3 | 4 | 69 |
| NEIS2070 (gmhA) | 99 | 42 | 9 | 3 | 4 | 74 |
| Kdo addition | ||||||
| NEIS0624 (kdsB) | 175 | 46 | 13 | 3 | 5 | 142 |
| NEIS1218 (kdsA) | 105 | 35 | 10 | 2 | 6 | 82 |
| NEIS1815 (kdsC) | 80 | 27 | 8 | 6 | 6 | 64 |
| NEIS1816 (kpsF) | 206 | 53 | 10 | 5 | 6 | 162 |
| NEIS2152 (kdtA) | 441 | 94 | 17 | 6 | 6 | 330 |
| Lipid A biosynthesis, acyltransferases | ||||||
| NEIS0168 (lpxA) | 135 | 46 | 15 | 5 | 6 | 104 |
| NEIS0171 (lpxD) | 216 | 52 | 15 | 6 | 6 | 166 |
| NEIS0421 (lpxL2) | 126 | 31 | 11 | 6 | 5 | 105 |
| NEIS1351 (lpxL) | 201 | 50 | 14 | 4 | 5 | 159 |
| Lipid A biosynthesis, other | ||||||
| NEIS0001 (lpxC) | 416 | 100 | 17 | 5 | 5 | 324 |
| NEIS0191 (lpxB) | 190 | 52 | 15 | 5 | 8 | 150 |
| NEIS0483 (lpxH) | 174 | 49 | 14 | 7 | 8 | 142 |
| NEIS0621 (lpxK) | 158 | 47 | 17 | 3 | 5 | 115 |
| NEIS1553 (lptA) | 353 | 93 | 24 | 9 | 10 | 272 |
| LOS α chain transferases | ||||||
| NEIS0899 (lst) | 281 | 53 | 15 | 7 | 7 | 224 |
| NEIS1618 (lgtF) | 141 | 47 | 14 | 5 | 6 | 103 |
| NEIS1900 (lgtE) | 360 | 75 | 31 | 13 | 5 | 285 |
| NEIS1901 (lgtB) | 347 | 62 | 27 | 12 | 6 | 270 |
| NEIS1902 (lgtA) | 191 | 47 | 13 | 8 | 8 | 151 |
| NEIS2154 (lgtC) | 26 | 8 | 5 | 1 | 0 | 22 |
| NEIS2155 (lgtD) | 254 | 64 | 18 | 8 | 9 | 203 |
| LOS inner core transferases | ||||||
| NEIS0291 (lot) | 262 | 62 | 17 | 5 | 5 | 203 |
| NEIS1456 (rfaF) | 230 | 72 | 16 | 7 | 7 | 169 |
| NEIS1619 (rfaK) | 184 | 53 | 11 | 5 | 6 | 151 |
| NEIS1986 (lpt3) | 228 | 52 | 14 | 5 | 6 | 183 |
| NEIS2011 (lgtG) | 80 | 26 | 11 | 3 | 6 | 62 |
| NEIS2012 (lpt6) | 59 | 22 | 10 | 4 | 5 | 44 |
| NEIS2134 (rfaC) | 251 | 55 | 23 | 7 | 6 | 196 |
| LOS transport/export | ||||||
| NEIS0304 (msbA) | 281 | 71 | 15 | 8 | 8 | 210 |
| NEIS0657 (rlpB) | 66 | 18 | 6 | 2 | 5 | 45 |
| NEIS1812 (yhbG) | 147 | 37 | 10 | 5 | 4 | 116 |
| NEIS1813 (ostA) | 94 | 26 | 4 | 2 | 1 | 71 |
| NEIS1814 (lptC) | 114 | 38 | 9 | 4 | 4 | 85 |
| UDP-GlcNAc synthesis | ||||||
| NEIS0015 (glmU) | 323 | 81 | 18 | 6 | 8 | 250 |
| UDP-glucose and UDP-galactose biosynthesis | ||||||
| NEIS0048 (galE) | 236 | 49 | 14 | 6 | 3 | 182 |
a Locus definitions are organized according to various steps in the biosynthetic process.