FIGURE 7.

Proposed model for proteaphagy. During logarithmic growth ∼70% of yeast proteasomes are nuclear. Nitrogen starvation induces autophagy of proteasomes. However, similar to the observations for ribosomes, two subcomplexes (CP and RP) show a different requirement for components that target them to the vacuole as well as different fates upon disruption of autophagy. This indicates that CP and RP dissociate. It is currently not clear whether this dissociation occurs prior to or following nuclear export resulting in two possible models of nitrogen starvation-induced proteaphagy.