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Inhibitors of Gα12/13 and Gβ/γ block ΔNT and -SL signaling activity. The RGS domain of p115RhoGEF, a Gα12/13 inhibitor, as well as the Gβ/γ inhibitor gallein, significantly block ΔNT and -SL signaling to NFAT for both receptors (5A-B: G1, 5C-D: B1). Results are from 3–6 independent experiments (± S.E. shown, *, p < 0.05; **, p < 0.01 versus G1/B1).
