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. 2015 Dec 16;291(7):3395–3410. doi: 10.1074/jbc.M115.680009

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FIGURE 3. — Binding profile of mature BMP9 and BMP9·pro-domain to ActRIIA, ActRIIB, ENG, and anti-mature BMP9 antibody. SPR sensorgrams of BMP9 binding to ActRIIA (A), ActRIIB (B), ENG (C), and anti-mature BMP9 (D) antibody BMP9-0087. Measured biomolecular interactions were evaluated using a regular 1:1 Langmuir binding model for B and D. Different concentrations are shown in black with maximum concentrations indicated, and the curve fittings are shown in red. For the fast interactions in A and C affinities were evaluated in an equilibrium steady state model from responses at the 150–160-s time window, with fitting depicted below the corresponding sensorgrams. RU, response units.