FIGURE 2.

DMF has anti-breast cancer activity both in vitro and in vivo. A, MS formation (solid line) and 2D cell growth (dashed line) in the indicated cell lines were measured after treatment with varying concentrations of DMF. The effect of DMF is plotted as percent of dimethyl sulfoxide vehicle (veh) control. B, representative pictures at ×10 magnification of MCF-7 MS formation upon treatment with DMF or the NFκB inhibitors IKK7 (5 μm) and Bay117082 (Bay, 10 μm). C, effect of DMF (30 mg/kg daily) on MDA-MB-231 xenograft tumor growth is indicated. #, p = 0.0002; ##, p = 0.003. Avg, average.