Table 2. Hematological values of male and female rats.
| Items | Main group (mg/kg/day) | Recovery group (mg/kg/day) | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| 0 | 25 | 100 | 400 | 0 | 400 | |
|
| ||||||
| Male | ||||||
| RBC (106/μL) | 7.63 ± 0.22 | 7.64 ± 0.11 | 7.55 ± 0.35 | 7.55 ± 0.31 | 7.99 ± 0.17 | 7.98 ± 0.09 |
| Hemoglobin (g/dL) | 15.5 ± 0.7 | 15.6 ± 0.8 | 15.3 ± 0.8 | 15.0 ± 0.6 | 14.8 ± 0.3 | 14.6 ± 0.4 |
| Hematocrit (%) | 44.5 ± 1.7 | 44.9 ± 1.6 | 43.6 ± 2.0 | 43.1 ± 1.5 | 43.8 ± 0.3 | 44.4 ± 1.0 |
| MCV (fL) | 58.4 ± 1.8 | 58.8 ± 1.8 | 57.7 ± 2.0 | 57.1 ± 1.3 | 54.8 ± 1.3 | 55.7 ± 1.5 |
| MCH (pg) | 20.3 ± 0.9 | 20.5 ± 0.9 | 20.2 ± 1.0 | 20.0 ± 0.6 | 18.5 ± 0.5 | 18.3 ± 0.5 |
| MCHC (g/μL) | 34.7 ± 1.0 | 34.8 ± 0.6 | 35.0 ± 0.8 | 34.9 ± 0.5 | 33.7 ± 0.6 | 32.9 ± 0.2* |
| Platelet (103/μL) | 1125 ± 102 | 1108 ± 86 | 1073 ± 114 | 1076 ± 69 | 1166 ± 147 | 1181 ± 162 |
| Reticulocyte (%) | 2.4 ± 0.5 | 2.5 ± 0.4 | 2.5 ± 0.4 | 2.3 ± 0.5 | 2.7 ± 0.6 | 3.2 ± 0.3 |
| WBC (103/μL) | 8.79 ± 3.59 | 7.98 ± 3.17 | 10.39 ± 1.90 | 8.02 ± 1.76 | 9.05 ± 4.60 | 7.80 ± 2.37 |
| Neutrophils (%) | 18.1 ± 6.6 | 19.1 ± 6.3 | 16.4 ± 4.0 | 15.9 ± 3.3 | 20.2 ± 4.7 | 20.9 ± 5.2 |
| Lymphocytes (%) | 77.9 ± 7.0 | 77.2 ± 6.1 | 79.5 ± 3.8 | 79.9 ± 3.1 | 75.7 ± 4.3 | 74.7 ± 5.9 |
| Monocytes (%) | 2.1 ± 0.7 | 1.9 ± 0.4 | 1.9 ± 0.3 | 2.3 ± 0.9 | 2.0 ± 0.4 | 2.3 ± 1.1 |
| Eosinophils (%) | 0.7 ± 0.2 | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.7 ± 0.3 | 1.1 ± 0.7 | 0.8 ± 0.1 |
| Basophils (%) | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| PT (second) | 17.3 ± 0.6 | 17.3 ± 0.7 | 17.3 ± 0.7 | 17.6 ± 0.8 | 16.7 ± 1.0 | 16.1 ± 0.7 |
| APTT (second) | 15.1 ± 0.8 | 14.4 ± 2.0 | 14.4 ± 0.9 | 14.3 ± 1.0 | 13.5 ± 3.3 | 11.2 ± 2.6 |
| No. of animals | 10 | 9 | 10 | 10 | 5 | 5 |
| Female | ||||||
| RBC (106/μL) | 7.32 ± 0.37 | 7.20 ± 0.29 | 7.31 ± 0.36 | 7.07 ± 0.26 | 7.54 ± 0.21 | 7.75 ± 0.33 |
| Hemoglobin (g/dL) | 14.4 ± 0.6 | 14.0 ± 0.5 | 14.1 ± 0.5 | 13.5 ± 0.3** | 14.2 ± 0.4 | 14.1 ± 0.5 |
| Hematocrit (%) | 42.2 ± 2.0 | 41.1 ± 1.8 | 41.7 ± 1.6 | 40.0 ± 1.2* | 41.7 ± 1.2 | 42.0 ± 1.5 |
| MCV (fL) | 57.7 ± 1.5 | 57.0 ± 1.1 | 57.1 ± 1.9 | 56.6 ± 1.7 | 55.3 ± 2.3 | 54.2 ± 0.9 |
| MCH (pg) | 19.8 ± 0.4 | 19.5 ± 0.4 | 19.4 ± 0.6 | 19.2 ± 0.6 | 18.9 ± 0.5 | 18.3 ± 0.3* |
| MCHC (g/μL) | 34.2 ± 0.5 | 34.2 ± 0.8 | 33.9 ± 0.3 | 33.9 ± 0.4 | 34.2 ± 1.0 | 33.7 ± 0.3 |
| Platelet (103/μL) | 1174 ± 170 | 1179 ± 142 | 1140 ± 148 | 1128 ± 138 | 1068 ± 119 | 1094 ± 98 |
| Reticulocyte (%) | 2.6 ± 2.1 | 2.5 ± 1.4 | 1.8 ± 0.5 | 2.5 ± 1.3 | 2.2 ± 0.7 | 1.5 ± 0.3 |
| WBC (103/μL) | 4.10 ± 1.01 | 4.37 ± 1.39 | 4.33 ± 1.03 | 5.17 ± 2.19 | 6.22 ± 1.81 | 4.54 ± 1.19 |
| Neutrophils (%) | 17.6 ± 6.9 | 14.4 ± 6.5 | 15.1 ± 5.0 | 20.4 ± 6.0 | 15.1 ± 6.5 | 14.7 ± 4.1 |
| Lymphocytes (%) | 79.2 ± 7.2 | 82.1 ± 7.1 | 81.2 ± 5.2 | 75.9 ± 6.0 | 81.1 ± 7.7 | 81.1 ± 4.9 |
| Monocytes (%) | 1.5 ± 0.4 | 1.9 ± 0.8 | 1.9 ± 0.7 | 2.1 ± 0.7 | 2.0 ± 1.3 | 2.0 ± 0.6 |
| Eosinophils (%) | 1.0 ± 0.4 | 0.8 ± 0.3 | 0.9 ± 0.3 | 0.9 ± 0.4 | 0.9 ± 0.4 | 1.1 ± 0.4 |
| Basophils (%) | 0.2 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| PT (second) | 18.5 ± 0.6 | 18.3 ± 0.6 | 18.1 ± 0.6 | 17.9 ± 0.8 | 18.9 ± 0.5 | 18.8 ± 0.9 |
| APTT (second) | 14.2 ± 0.8 | 13.6 ± 0.7 | 13.9 ± 1.1 | 13.5 ± 1.1 | 13.9 ± 0.8 | 13.7 ± 1.1 |
| No. of animals | 10 | 10 | 10 | 10 | 5 | 5 |
RBC: red blood cell count, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration, WBC: white blood cell count, PT: prothrombin time, APTT: active partial thromboplastin time.
Significantly different from vehicle control: *p<0.05, **p < 0.01. Values are mean ± S.D.