Table 4. Absolute and relative organ weights of male and female rats.
| Items | Main group (mg/kg/day) | Recovery group (mg/kg/day) | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| 0 | 25 | 100 | 400 | 0 | 400 | |
|
| ||||||
| Male | ||||||
| Body weighta) (g) | 375.9 ± 21.7 | 368.1 ± 36.5 | 374.4 ± 27.4 | 339.4 ± 25.9* | 453.1 ± 22.3 | 410.1 ± 25.8* |
| Brain (g) | 2.02 ± 0.08 | 1.97 ± 0.13 | 1.97 ± 0.10 | 1.97 ± 0.06 | 2.02 ± 0.16 | 2.04 ± 0.06 |
| % to body weight | 0.54 ± 0.03 | 0.54 ± 0.04 | 0.53 ± 0.04 | 0.58 ± 0.05* | 0.44 ± 0.03 | 0.50 ± 0.04* |
| Pituitary (g) | 0.0113 ± 0.0012 | 0.0101 ± 0.0027 | 0.0111 ± 0.0015 | 0.0100 ± 0.0012 | 0.0106 ± 0.0011 | 0.0118 ± 0.0012 |
| % to body weight | 0.0030 ± 0.0002 | 0.0027 ± 0.0006 | 0.0030 ± 0.0003 | 0.0029 ± 0.0003 | 0.0024 ± 0.0003 | 0.0029 ± 0.0003* |
| Heart (g) | 1.26 ± 0.12 | 1.20 ± 0.10 | 1.25 ± 0.08 | 1.12 ± 0.08** | 1.34 ± 0.06 | 1.24 ± 0.11 |
| % to body weight | 0.34 ± 0.03 | 0.33 ± 0.03 | 0.33 ± 0.02 | 0.33 ± 0.01 | 0.30 ± 0.02 | 0.31 ± 0.01 |
| Lungs (g) | 1.45 ± 0.13 | 1.39 ± 0.09 | 1.44 ± 0.10 | 1.38 ± 0.07 | 1.55 ± 0.04 | 1.45 ± 0.14 |
| % to body weight | 0.39 ± 0.02 | 0.38 ± 0.02 | 0.39 ± 0.02 | 0.41 ± 0.02 | 0.35 ± 0.02 | 0.35 ± 0.04 |
| Liver (g) | 11.85 ± 1.62 | 11.50 ± 1.34 | 12.75 ± 1.55 | 12.27 ± 1.91 | 13.76 ± 1.61 | 12.20 ± 1.25 |
| % to body weight | 3.15 ± 0.33 | 3.12 ± 0.19 | 3.40 ± 0.20 | 3.60 ± 0.30** | 3.03 ± 0.27 | 2.97 ± 0.17 |
| Spleen (g) | 0.77 ± 0.15 | 0.67 ± 0.11 | 0.71 ± 0.11 | 0.62 ± 0.08* | 0.86 ± 0.28 | 0.77 ± 0.18 |
| % to body weight | 0.20 ± 0.04 | 0.18 ± 0.02 | 0.19 ± 0.04 | 0.18 ± 0.03 | 0.19 ± 0.06 | 0.19 ± 0.04 |
| Kidneys (g) | 2.81 ± 0.28 | 2.79 ± 0.31 | 2.98 ± 0.23 | 2.82 ± 0.34 | 2.99 ± 0.17 | 3.01 ± 0.26 |
| % to body weight | 0.75 ± 0.04 | 0.76 ± 0.05 | 0.80 ± 0.03* | 0.83 ± 0.06** | 0.66 ± 0.02 | 0.73 ± 0.03** |
| Adrenals (g) | 0.0600 ± 0.0090 | 0.0597 ± 0.0083 | 0.0609 ± 0.0112 | 0.0675 ± 0.0069 | 0.0668 ± 0.0087 | 0.0622 ± 0.0107 |
| % to body weight | 0.0160 ± 0.0021 | 0.0162 ± 0.0015 | 0.0162 ± 0.0022 | 0.0200 ± 0.0024** | 0.0148 ± 0.0018 | 0.0152 ± 0.0026 |
| Testes (g) | 3.26 ± 0.33 | 3.30 ± 0.21 | 3.38 ± 0.31 | 3.23 ± 0.13 | 3.35 ± 0.13 | 3.41 ± 0.18 |
| % to body weight | 0.87 ± 0.08 | 0.90 ± 0.07 | 0.90 ± 0.07 | 0.95 ± 0.06 | 0.74 ± 0.06 | 0.84 ± 0.08 |
| Prostate gland (g) | 0.50 ± 0.10 | 0.47 ± 0.10 | 0.51 ± 0.14 | 0.38 ± 0.12 | 0.55 ± 0.08 | 0.54 ± 0.08 |
| % to body weight | 0.13 ± 0.02 | 0.13 ± 0.03 | 0.14 ± 0.03 | 0.11 ± 0.04 | 0.12 ± 0.02 | 0.13 ± 0.02 |
| No. of animals | 10 | 9 | 10 | 10 | 5 | 5 |
| Female | ||||||
| Body weighta) (g) | 213.7 ± 16.1 | 231.7 ± 7.6 | 219.0 ± 21.3 | 221.7 ± 17.0 | 239.8 ± 25.2 | 246.7 ± 25.0 |
| Brain (g) | 1.87 ± 0.06 | 1.85 ± 0.06 | 1.81 ± 0.08 | 1.82 ± 0.09 | 1.87 ± 0.12 | 1.88 ± 0.09 |
| % to body weight | 0.88 ± 0.08 | 0.80 ± 0.03 | 0.84 ± 0.11 | 0.83 ± 0.08 | 0.78 ± 0.07 | 0.77 ± 0.12 |
| Pituitary (g) | 0.0128 ± 0.0013 | 0.0135 ± 0.0018 | 0.0128 ± 0.0017 | 0.0139 ± 0.0013 | 0.0128 ± 0.0031 | 0.0151 ± 0.0024 |
| % to body weight | 0.0060 ± 0.0006 | 0.0058 ± 0.0008 | 0.0059 ± 0.0009 | 0.0063 ± 0.0004 | 0.0053 ± 0.0010 | 0.0061 ± 0.0006 |
| Heart (g) | 0.76 ± 0.07 | 0.82 ± 0.05 | 0.75 ± 0.10 | 0.80 ± 0.06 | 0.79 ± 0.09 | 0.86 ± 0.10 |
| % to body weight | 0.36 ± 0.01 | 0.36 ± 0.01 | 0.34 ± 0.03 | 0.36 ± 0.02 | 0.33 ± 0.02 | 0.35 ± 0.03 |
| Lungs (g) | 1.06 ± 0.07 | 1.09 ± 0.06 | 1.10 ± 0.15 | 1.27 ± 0.11** | 1.09 ± 0.12 | 1.13 ± 0.07 |
| % to body weight | 0.49 ± 0.03 | 0.47 ± 0.02 | 0.50 ± 0.04 | 0.57 ± 0.06* | 0.45 ± 0.02 | 0.46 ± 0.03 |
| Liver (g) | 6.35 ± 0.66 | 7.15 ± 0.47 | 6.84 ± 1.05 | 8.05 ± 0.70** | 6.67 ± 0.98 | 7.08 ± 1.17 |
| % to body weight | 2.97 ± 0.14 | 3.09 ± 0.19 | 3.11 ± 0.25 | 3.64 ± 0.26** | 2.77 ± 0.16 | 2.85 ± 0.25 |
| Spleen (g) | 0.52 ± 0.14 | 0.51 ± 0.10 | 0.48 ± 0.07 | 0.52 ± 0.15 | 0.57 ± 0.07 | 0.51 ± 0.04 |
| % to body weight | 0.24 ± 0.07 | 0.22 ± 0.05 | 0.22 ± 0.04 | 0.23 ± 0.06 | 0.24 ± 0.04 | 0.21 ± 0.01 |
| Kidneys (g) | 1.58 ± 0.08 | 1.77 ± 0.12** | 1.71 ± 0.14 | 1.83 ± 0.16** | 1.62 ± 0.16 | 1.73 ± 0.18 |
| % to body weight | 0.74 ± 0.04 | 0.76 ± 0.04 | 0.78 ± 0.06 | 0.83 ± 0.07** | 0.68 ± 0.05 | 0.71 ± 0.05 |
| Adrenals (g) | 0.0681 ± 0.0069 | 0.0686 ± 0.0119 | 0.0679 ± 0.0049 | 0.0740 ± 0.0067 | 0.0690 ± 0.0100 | 0.0772 ± 0.0092 |
| % to body weight | 0.0320 ± 0.0039 | 0.0297 ± 0.0055 | 0.0311 ± 0.0021 | 0.0336 ± 0.0046 | 0.0288 ± 0.0033 | 0.0313 ± 0.0027 |
| Ovary (g) | 0.0877 ± 0.0093 | 0.0911 ± 0.0100 | 0.0827 ± 0.0150 | 0.0935 ± 0.0123 | 0.0821 ± 0.0134 | 0.0865 ± 0.0112 |
| % to body weight | 0.0411 ± 0.0044 | 0.0394 ± 0.0045 | 0.0379 ± 0.0069 | 0.0422 ± 0.0054 | 0.0342 ± 0.0036 | 0.0353 ± 0.0053 |
| Uterus (g) | 0.47 ± 0.18 | 0.47 ± 0.11 | 0.53 ± 0.23 | 0.53 ± 0.20 | 0.64 ± 0.18 | 0.68 ± 0.24 |
| % to body weight | 0.22 ± 0.09 | 0.20 ± 0.05 | 0.24 ± 0.09 | 0.24 ± 0.10 | 0.27 ± 0.09 | 0.28 ± 0.08 |
| No. of animals | 10 | 10 | 10 | 10 | 5 | 5 |
a)The body weights were measured right before necropsy after overnight fasting.
Significantly different from vehicle control: *p<0.05, **p < 0.01. Values are mean ± S.D.