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. 2016 Feb 12;6:21025. doi: 10.1038/srep21025

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Copyright © 2016, Macmillan Publishers Limited

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(A) The structure of arrestin-3 (PDB: 3P2D;²⁷) with the three peptides implicated in JNK3 binding²³ shown in red (T1A), blue (T3), and green (T6). (B) COS7 cells co-expressed HA-ASK1 and HA-JNK3α2 without (Control) or with full-length arrestin-3 (Arr3), YFP, or indicated YFP-tagged JNK3-binding peptides. The upper three blots show expression levels of indicated proteins; the lower blot shows that T1A facilitates JNK3α2 phosphorylation more efficiently than full-length arrestin-3. (C) COS7 cells co-expressed HA-ASK1 and HA-JNK3α2 with YFP (Control) or different concentrations of YFP-T1A. The upper two blots show expression levels of indicated proteins; the lower blot shows biphasic dependence of JNK3α2 phosphorylation on T1A level. Full blots are shown in Supplemental Fig. S4b (panel B) and S4c (panel C).