Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) The profibrotic cytokines TGFβ1 and TNFα can induce WISP1 presumably via NF-κB in phLFs, which results in WISP1-dependent IL-6 production and increased proliferation of phLFs. (B) In the absence of WISP1, decreased IL-6 levels lead to reduced fibroblast proliferation. Our working hypothesis is that WISP1 controls IL-6 expression via a positive feedback on NF-κB.
