Figure 3.

Gene Ontology (GO) Term Mapper indicates a variety of processes affected by nicotinamide (NAM) treatment. The 55 most sensitive deletions are in genes with nuclear functions such as DNA replication and repair, and mitosis. A subset of these deletions is in genes with functions in lipid metabolism and organelle organization. Screen frequency (blue) and genome frequency (red) represent the frequency of observing genes with the respective GO terms on the y-axis. Note that the frequency of occurrence of genes in a given category, except for RNA polymerase II transcription, is several fold higher in our screen compared to the genome.